CNS DEGENERATIVE DISORDERS NOTES

“HUNTINGTON DISEASE”

“ Autosomal dominant inherited neurodegenerative disease associated with choreoathetosis and dementia. The average age of onset is 40 years. MRI •  Heart or Box-shaped enlargement of the frontal horns (due to atrophy of the caudate resulting in ex vacuo dilatation of the frontal horns).•  There may be iron deposition in the basal ganglia, which is low on …

“HUNTINGTON DISEASE” Read More »

CAUSES OF CEREBELLAR ATROPHY (‘GRAMP PA’S’)

“ •  Gluten insensitivity •  Radiation•  Ataxic telangiectasia•  Multisystem atrophy•  Phenytoin•  Paraneoplastic syndrome (e.g. bronchial tumour)•  Alcohol•  Steroids” For Radiology Cases, Discussion join: Radiology Made Easy on Facebook  Subscribe to our youtube channel for FRCR radiology case discussion  Join our Telegram group: Radiology Made Easy   

“MULTISYSTEM ATROPHY”

“ A progressive disease with pyramidal, extrapyramidal and autonomic symptoms (combination of Parkinsonian and cerebellar signs). MRI •  Severe brainstem and cerebellar atrophy and high signal in the pons, the ‘hot cross bun’ sign•  Low T2 signal in the basal ganglia (iron deposition) ” For Radiology Cases, Discussion join: Radiology Made Easy on Facebook  Subscribe …

“MULTISYSTEM ATROPHY” Read More »

“LEWY BODY DEMENTIA”

“ Associated with Parkinsonian features. There is fluctuating cognitive impairment and visual hallucinations. MRI •  Similar to Alzheimer disease, but less sparing of the occipital lobes.•  Affects the parietal and occipital lobes and the cerebellum.” For Radiology Cases, Discussion join: Radiology Made Easy on Facebook  Subscribe to our youtube channel for FRCR radiology case discussion  …

“LEWY BODY DEMENTIA” Read More »

“ALZHEIMER DISEASE”

“ This is the most common degenerative dementia. It affects up to 50% of those aged >85 years. CT/MRI •  Hippocampal atrophy is the cardinal feature. Perihippocampal fissures are more prominent.•  Focal atrophic change in the medial temporal lobe with subsequent marked enlargement of the temporal horns.•  Suprasellar cisterns and Sylvian fissures are also dilated …

“ALZHEIMER DISEASE” Read More »

“PROGRESSIVE SUPRANUCLEAR PALSY (PSP)”

“ This is a combination of Parkinson disease, supranuclear ophthalmoplegia (paralysis of downwards gaze), pseudobulbar palsy and early-onset dementia. MRI •  Atrophy of the midbrain, globus pallidus and frontal lobes•  Dilatation of the third ventricle, enlargement of the interpeduncular cistern ” For Radiology Cases, Discussion join: Radiology Made Easy on Facebook  Subscribe to our youtube …

“PROGRESSIVE SUPRANUCLEAR PALSY (PSP)” Read More »

“PICK DISEASE”

“ This is a rare frontotemporal dementia with onset in young adults. CT/MRI •  Asymmetrical temporal (and sometimes) frontal lobe atrophy•  Similar pattern seen with alcoholism and schizophrenia” For Radiology Cases, Discussion join: Radiology Made Easy on Facebook  Subscribe to our youtube channel for FRCR radiology case discussion  Join our Telegram group: Radiology Made Easy  …

“PICK DISEASE” Read More »

“PANTOTHENATE KINASE DEFICIENCY”

“ Also known as Hallervorden-Spatz syndrome, this is a hereditary movement disorder. MRI •  Low T1 and T2 signal in both pallidum (iron deposition). This gives the ‘eye of the tiger’ sign.” For Radiology Cases, Discussion join: Radiology Made Easy on Facebook  Subscribe to our youtube channel for FRCR radiology case discussion  Join our Telegram …

“PANTOTHENATE KINASE DEFICIENCY” Read More »

Scroll to Top