“CANAVAN DISEASE”

From build-up of N-acetylaspartate (NAA) from enzyme deficiency. 
Begins in first year of life. 
Macrocephaly and brain enlargement.
MRI

•  Involvement of all white matter and deep grey matter (especially the basal ganglia and thalami)

•  involving the subcortical U-fibers 
•  Marked NAA peak on MRI spectroscopy





 

Leave a Comment

Your email address will not be published.

Scroll to Top