1. What is the diagnosis?

A. Chondrosarcoma

B. Osteosarcoma

C. Fibrous Dysplasia

D. Mets (breast or lung)

2. Fibrous Dysplasia vs Pagets?

A. Fibrous Dysplasia involves the inner table

B. Pagets involves the inner table

C. Fibrous Dysplasia never crosses sutures

D. Fibrous Dysplasia spares the sinuses

3. What if this patient had “cafe au lait” spots?

A. Mazabraud Syndrome

B. McCune-Albright Syndrome

C. Jaffe-Campanacci Syndrome

D. Rhinophyma

4. What if this patient had intramuscular myxomas?

A. Mazabraud Syndrome

B. McCune-Albright Syndrome

C. Jaffe-Campanacci Syndrome

D. Rhinophyma

Answers

1. What is the diagnosis?

A. Chondrosarcoma

B. Osteosarcoma

C. Fibrous Dysplasia

D. Mets (breast or lung)

2. Fibrous Dysplasia vs Pagets?

A. Fibrous Dysplasia involves the inner table

B. Pagets involves the inner table

C. Fibrous Dysplasia never crosses sutures

D. Fibrous Dysplasia spares the sinuses

3. What if this patient had “cafe au lait” spots?

A. Mazabraud Syndrome

B. McCune-Albright Syndrome

C. Jaffe-Campanacci Syndrome

D. Rhinophyma

4. What if this patient had intramuscular myxomas?

A. Mazabraud Syndrome

B. McCune-Albright Syndrome

C. Jaffe-Campanacci Syndrome

D. Rhinophyma

Fibrous Dysplasia

Benign tumor like process, that occurs as a result of screwed up osteoblastic function. The result is the progressive replacement of normal bone with immature woven bone.

Key Feature :

– ”Leontiasis Ossea ” or “Lion Face” is the historic term used for craniofacial F. D.

– “Ground Glass” is the classic buzzword. – Pagets is the primary DDx. The difference is that F. D. spares the inner table, and Pagets classically involves it.

McCune Albright Syndrome: precocious puberty + ‘cafe au lait’ spots + polyostotic fibrous dysplasia

Mazabraud Syndrome: polyostotic fibrous dysplasia + multiple soft tissue myxomas (usually in large muscle groups). This has an increased risk of malignant transformation